Depends on your definition of ‘work’.
FILTER_VALIDATE_EMAIL will work for the vast majority of use cases - actual, human-entered emails.
PHP’s filter_var uses the following regular expression to validate emails:
/^(?!(?:(?:\x22?\x5C[\x00-\x7E]\x22?)|(?:\x22?[^\x5C\x22]\x22?)){255,})(?!(?:(?:\x22?\x5C[\x00-\x7E]\x22?)|(?:\x22?[^\x5C\x22]\x22?)){65,}@)(?:(?:[\x21\x23-\x27\x2A\x2B\x2D\x2F-\x39\x3D\x3F\x5E-\x7E]+)|(?:\x22(?:[\x01-\x08\x0B\x0C\x0E-\x1F\x21\x23-\x5B\x5D-\x7F]|(?:\x5C[\x00-\x7F]))*\x22))(?:\.(?:(?:[\x21\x23-\x27\x2A\x2B\x2D\x2F-\x39\x3D\x3F\x5E-\x7E]+)|(?:\x22(?:[\x01-\x08\x0B\x0C\x0E-\x1F\x21\x23-\x5B\x5D-\x7F]|(?:\x5C[\x00-\x7F]))*\x22)))*@(?:(?:(?!.*[^.]{64,})(?:(?:(?:xn--)?[a-z0-9]+(?:-[a-z0-9]+)*\.){1,126}){1,}(?:(?:[a-z][a-z0-9]*)|(?:(?:xn--)[a-z0-9]+))(?:-[a-z0-9]+)*)|(?:\[(?:(?:IPv6:(?:(?:[a-f0-9]{1,4}(?::[a-f0-9]{1,4}){7})|(?:(?!(?:.*[a-f0-9][:\]]){7,})(?:[a-f0-9]{1,4}(?::[a-f0-9]{1,4}){0,5})?::(?:[a-f0-9]{1,4}(?::[a-f0-9]{1,4}){0,5})?)))|(?:(?:IPv6:(?:(?:[a-f0-9]{1,4}(?::[a-f0-9]{1,4}){5}:)|(?:(?!(?:.*[a-f0-9]:){5,})(?:[a-f0-9]{1,4}(?::[a-f0-9]{1,4}){0,3})?::(?:[a-f0-9]{1,4}(?::[a-f0-9]{1,4}){0,3}:)?)))?(?:(?:25[0-5])|(?:2[0-4][0-9])|(?:1[0-9]{2})|(?:[1-9]?[0-9]))(?:\.(?:(?:25[0-5])|(?:2[0-4][0-9])|(?:1[0-9]{2})|(?:[1-9]?[0-9]))){3}))\]))$/iD
Yes, that’s ugly as sin. But it’s effective in -almost- every case - it has the best ‘correct’ ratio of given attempts to solve the problem.
Noted exceptions include that it thinks “”@sitepoint.com is valid, and blar@123.111.101.100 to be invalid.
There are a few more, but you get the point - they’re edge cases at best.