If you’re familiar with regular expressions, it’s trivial. If you’re not, mod_rewrite is not the tool for you.
For instance, your URI is beautiful/?option=content&cat_id=1&itemId=1.sf and you want to rewrite beautiful/content/about to that URI.
Therefore, you need to capture content and … duh … about is not a value in the query string.
Normally, you’d have beautiful/value1/value2/value3 and redirect that to beautiful/index.php?option=value1&cat_id=value2&itemId=value3. You only have two values so, unless one of your values is fixed, you just can’t do this.
Have you change all those rewrite mod modules at httpd.conf? If you had already done so, perhaps it should work fine. Or you can post your sample URL for us to know better.