I’m a quadriplegic (I can’t control anything below my head) and web developer. Just with the use of a mouth stick though, I can easily use a keyboard and mouse pretty well like everyone else.
The ADA has helped in a lot of ways for more than just those of with disabilities. Alt text on images helps mobile users decide whether or not to view an image and works with search engines. There’s a lot that can still be done, but I have seen quite a good amount of improvement in the past 25 years.