When using photoshop slices, make sure all the lines touch and that SNAP is on (View > Snap) so that you don't get any gaps. I would keep it very direct, horizontal lines. IF you have to make a link or a navigation I would use image maps.
But if you want to be in the year 2012, I would learn how to convert it into CSS and Div layers. There are a million and one tutorials on how to convert a photoshop layout into a div and CSS layout. It's how i learned!