Why do you prefer desktop? And do you use a desktop, or do circumstances impose to use a laptop?
Please answer these questions to give the thread some chance of becoming interesting. If it turns into a list of laptop/desktop answers it's going to be closed real soon.
Me, I don't have a preference. I use a laptop, because I don't work always in the same office. I prefer a "desktop" keyboard and screen, though, but that's easily solved when I'm in the office: I just plug the laptop in a docking station.